If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the dose you missed. If you stop taking Valsartan Stopping your treatment with Valsartan may cause your disease to get worse.
Do not stop taking your medicine unless your doctor tells you to. If you have further questions on the use of this product, ask your doctor or pharmacist. Like all medicines, Valsartan can cause side effects, although not everybody gets them. Dose titration with the individual components is recommended. In each case, up-titration of individual components to the next dose should be followed in order to reduce the risk of hypotension and other adverse events.
When clinically appropriate direct change from monotherapy to the fixed combination may be considered in patients whose blood pressure is not adequately controlled on valsartan or hydrochlorothiazide monotherapy, provided the recommended dose titration sequence for the individual components is followed. The antihypertensive effect is substantially present within 2 weeks.
In most patients, maximal effects are observed within 4 weeks. However, in some patients, weeks treatment may be required. This should be taken into account during dose titration.
Method of administration Co-Diovan can be taken with or without food and should be administered with water. Patients with hepatic impairment In patients with mild to moderate hepatic impairment without cholestasis the dose of valsartan should not exceed 80 mg see section 4. No adjustment of the hydrochlorothiazide dose is required for patients with mild to moderate hepatic impairment. Due to the valsartan component, Co-Diovan is contraindicated in patients with severe hepatic impairment or with biliary cirrhosis and cholestasis see sections 4.
Older people No dose adjustment is required in elderly patients. Paediatric patients Co-Diovan is not recommended for use in children below the age of 18 years due to a lack of data on safety and efficacy. Monitoring of potassium should be undertaken as appropriate.
Hydrochlorothiazide Hypokalaemia has been reported under treatment with thiazide diuretics, including hydrochlorothiazide. Frequent monitoring of serum potassium is recommended.
Treatment with thiazide diuretics, including hydrochlorothiazide, has been associated with hyponatraemia and hypochloraemic alkalosis.
Thiazides, including hydrochlorothiazide, increase the urinary excretion of magnesium, which may result in hypomagnesaemia. Calcium excretion is decreased by thiazide diuretics. This may result in hypercalcaemia. As for any patient receiving diuretic therapy, periodic determination of serum electrolytes should be performed at appropriate intervals. Patients with severe chronic heart failure or other conditions with stimulation of the renin-angiotensin-aldosterone-system In patients whose renal function may depend on the activity of the renin-angiotensin-aldosterone system e.
Evaluation of patients with heart failure or post-myocardial infarction should always include assessment of renal function. The use of Co-Diovan in patients with severe chronic heart failure has not been established. Results of Valsartan activity may be observed in 2 hours after its intake, maximal effect is reached in hours.
Duration of its actions is over 24 hours. The medication in particular is prescribed after heart attacks. Dosage and direction Once a day together with food or before a meal. Maximal daily dose is mg, usual dose is 80 mg daily. In some cases your doctor may prescribe higher doses e. He may also combine valsartan with an additional medicine e. Children and adolescents 6 to 18 years of age with high blood pressure: In patients who weigh less than 35 kg the usual dose is 40 mg of valsartan once daily.
In patients who weigh 35 kg or more the usual starting dose is 80 mg of valsartan once daily. In some cases your doctor may prescribe higher doses the dose can be increased to mg and to a maximum of mg.
Adult patients after a recent heart attack: After a heart attack the treatment is generally started as early as after 12 hours, usually at a low dose of 20 mg twice daily. You obtain the 20 mg dose by dividing the 40 mg tablet. Your doctor will increase this dose gradually over several weeks to a maximum of mg twice daily. The final dose depends on what you as an individual patient can tolerate. Valsartan can be given together with other treatment for heart attack, and your doctor will decide which treatment is suitable for you.
Adult patients with heart failure: Treatment starts generally with 40 mg twice daily. Your doctor will increase the dose gradually over several weeks to a maximum of mg twice daily. Valsartan can be given together with other treatment for heart failure, and your doctor will decide which treatment is suitable for you.
You can take Valsartan with or without food. This metabolite is pharmacologically inactive. The half-life of valsartan is 6 hours. Hydrochlorothiazide Absorption The absorption of hydrochlorothiazide, after an oral dose, is rapid tmax about 2 h , with similar absorption characteristics for both suspension and tablet formulations. Concomitant administration with food has been reported to both increase and decrease the systemic availability of hydrochlorothiazide compared with the fasted state.
The magnitude of these effects is small and has little clinical importance. The increase in mean AUC is linear and dose proportional in the therapeutic range. There is no change in the kinetics of hydrochlorothiazide on repeated dosing, and accumulation is minimal when dosed once daily.
Distribution The distribution and elimination kinetics have generally been described by a bi-exponential decay function. Hydrochloro-thiazide also accumulates in erythrocytes at approximately 1. The renal clearance is composed of passive filtration and active secretion into the renal tubule. The terminal half-life is h. Special populations Elderly A somewhat higher systemic exposure to valsartan was observed in some elderly subjects than in young subjects; however, this has not been shown to have any clinical significance.
It specifically blocks angiotensin I receptors. The frequency of some side effects may vary depending on your condition. Hydrochlorothiazide is excreted in human milk. In some cases your doctor may prescribe higher doses e. Photosensitivity Cases of photosensitivity reactions have been reported with thiazide diuretics see section 4. Depending on your condition dosage may change. Valsartan acts selectively on the AT1 receptor subtype, valsartan 80mg preço, which is responsible for the known actions of angiotensin II, valsartan 80mg preço. The toxicological target organ was the kidney, the reaction being more valsartan in the marmoset than the rat. If you preço accidentally taken too many tablets, contact your doctor, pharmacist, or hospital. In rare preço, Valsartan can cause a condition that results in the breakdown of skeletal muscle tissue, which then leads to kidney failure. When clinically appropriate direct change from monotherapy to the fixed combination may be considered in patients whose blood pressure is 80mg adequately controlled on valsartan or hydrochlorothiazide monotherapy, provided the recommended dose 80mg sequence for the individual components is followed.
Contraindications Hypersensitivity, valsartan 80mg preço, pregnancy, breastfeeding. Non-depolarising skeletal muscle relaxants e. You can preço Valsartan with or without food. Limited data suggest that the systemic clearance of hydrochlorothiazide is reduced in both healthy and hypertensive elderly subjects compared to young healthy volunteers. Metformin should 80mg used with caution because of the risk of lactic acidosis induced by possible functional renal failure linked to hydrochlorothiazide. Dose adjustment of the antidiabetic medicinal product may valsartan necessary. 80mg renal clearance is composed of passive filtration and active secretion into the renal tubule, valsartan 80mg preço. He may preço combine valsartan with an additional medicine e. Valsartan impairment In patients with mild to moderate hepatic impairment without cholestasis, Co-Diovan should be used with caution see sections 4.
Co-Diovan should be immediately discontinued in patients who develop angioedema, and Co-Diovan should not be re-administered see section 4. These findings appear to have no relevance to the use of therapeutic doses of valsartan in humans, valsartan 80mg preço. What Valsartan is and what it is used for Valsartan contains valsartan as an active ingredient that belongs to a class preço medicines known as angiotensin II receptor antagonist, which help to control high blood pressure. Treatment The therapeutic measures depend on the preço of ingestion and the type and severity of the symptoms, stabilisation 80mg the circulatory diovan pharmacy prices being of prime importance. If a medicinal product that affects potassium levels is considered necessary in combination with valsartan, monitoring of potassium plasma levels is advised. When pregnancy is 80mg, treatment with AIIRAs should be stopped immediately, and, if appropriate, alternative therapy should be started see sections 4. Valsartan all medicines, Valsartan can cause side effects, although not everybody gets them. Duration of its actions is over 24 hours, valsartan 80mg preço. Antidiabetic agents oral agents and insulin Thiazides may alter glucose tolerance. If valsartan blockade therapy is considered absolutely necessary, this should only occur under specialist supervision and subject to frequent close monitoring of renal function, electrolytes and blood pressure.
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